Pericentric chromatin loops function as a nonlinear spring in mitotic force balance
نویسندگان
چکیده
منابع مشابه
Pericentric chromatin loops function as a nonlinear spring in mitotic force balance
The mechanisms by which sister chromatids maintain biorientation on the metaphase spindle are critical to the fidelity of chromosome segregation. Active force interplay exists between predominantly extensional microtubule-based spindle forces and restoring forces from chromatin. These forces regulate tension at the kinetochore that silences the spindle assembly checkpoint to ensure faithful chr...
متن کاملPericentric Chromatin Is an Elastic Component of the Mitotic Spindle
BACKGROUND Prior to chromosome segregation, the mitotic spindle bi-orients and aligns sister chromatids along the metaphase plate. During metaphase, spindle length remains constant, which suggests that spindle forces (inward and outward) are balanced. The contribution of microtubule motors, regulators of microtubule dynamics, and cohesin to spindle stability has been previously studied. In this...
متن کاملChromatin Switches and Loops
A mechanism reveals how Swi6 spreads heterochromatin, silencing gene expression. HP1 Spreads the Word A classic example of how chromatin architecture regulates gene expression is the formation and spread of heterochromatin, a repressive state marked by histone H3 lysine 9 methylation (H3K9Me). In humans, heterochromatin protein 1 (HP1) binds to H3K9Me and is required for spreading of heterochro...
متن کاملPericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis
BACKGROUND Cohesin proteins link sister chromatids and provide the basis for tension between bioriented sister chomatids in mitosis. Cohesin is concentrated at the centromere region of the chromosome despite the fact that sister centromeres can be separated by 800 nm in vivo. The function of cohesin at sites of separated DNA is unknown. RESULTS We provide evidence that the kinetochore promote...
متن کاملCohesin, condensin, and the intramolecular centromere loop together generate the mitotic chromatin spring
Sister chromatid cohesion provides the mechanistic basis, together with spindle microtubules, for generating tension between bioriented chromosomes in metaphase. Pericentric chromatin forms an intramolecular loop that protrudes bidirectionally from the sister chromatid axis. The centromere lies on the surface of the chromosome at the apex of each loop. The cohesin and condensin structural maint...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.201208163